Chronic skin conditions can be persistent and significantly impact quality of life. For M., a 48-year-old woman, chronic dermatitis had been a struggle for 27 years. The condition began after she contracted cytomegalovirus at 21, following childbirth, and never fully resolved. Her skin developed pale red maculopapular eruptions—itchy and burning, similar to sunburn—spreading across her legs, thighs, abdomen, arms, and elbows. Symptoms worsened before her menstrual cycle and improved afterward. Stress aggravated the condition, leading to severe itching, disrupted sleep, and digestive discomfort, including morning nausea, constipation, and bloating. While steroids provided temporary relief, the rash always returned after discontinuation.